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KMID : 0032220120240030341
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Annals of Dermatology
2012 Volume.24 No. 3 p.341 ~ p.344
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Successful Treatment of Alopecia Areata with Topical Calcipotriol
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Kim Dong-Ha
Lee Jin-Woong
Kim In-Su
Choi Sun-Young
Lim Yun-Young
Kim Hyeong-Min
Kim Beom-Joon
Kim Myeung-Nam
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Abstract
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Alopecia areata (AA) is an inflammatory hair loss of unknown etiology. AA is chronic and relapsing, and no effective cure or preventive treatment has been established. Vitamin D was recently reported to be important in cutaneous immune modulation as well as calcium regulation and bone metabolism. It is well known that areata is common clinical finding in patients with vitamin D deficiency, vitamin D-resistant rickets, or vitamin D receptor (VDR) mutation. The biological actions of vitamin D3 derivatives include regulation of epidermal cell proliferation and differentiation and modulation of cytokine production. These effects might explain the efficacy of vitamin D3 derivatives for treating AA. In this study, we report a 7-year-old boy with reduced VDR expression in AA, recovery of whom was observed by topical application of calcipotriol, a strong vitamin D analog. (Ann Dermatol 24(3) 341∼344, 2012)
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KEYWORD
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Alopecia areata, Calcipotriol, Therapeutics, Vitamin D
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